Androgen Receptor Expression Helps to Differentiate BCC From Trichoblastoma and Trichoepithelioma
Identifieur interne : 008548 ( Main/Exploration ); précédent : 008547; suivant : 008549Androgen Receptor Expression Helps to Differentiate BCC From Trichoblastoma and Trichoepithelioma
Auteurs : L. Izikson ; A. Bhan [États-Unis] ; A. ZembowiczSource :
- Journal of Cutaneous Pathology [ 0303-6987 ] ; 2005-01.
Abstract
Histological differentiation between basal cell carcinoma and benign trichoblastic neoplasms such as trichoepithelioma and trichoblastoma can be difficult on small biopsies. Therefore, several attempts have been made to identify immunohistochemical differences between these entities. Recent studies showed androgen receptor expression in a number of mature epithelial structures in the skin and in epithelial neoplasms including basal cell carcinoma. In contrast, androgen receptor expression was absent in mature hair follicles or the few trichogenic neoplasms studied to date. These findings suggested that androgen receptor expression might be a useful adjunct in the histological differential diagnosis between basal cell carcinoma and benign trichoblastic neoplasms. Therefore, we performed immunohistochemical analysis of androgen receptor expression in 32 basal cell carcinomas and 10 benign trichoblastic tumors (6 trichoepitheliomas and 4 trichoblastomas). In our study, expression of androgen receptor was detected in 78% of basal cell carcinomas. None of the trichoblastic tumors showed any androgen receptor immunoreactivity. These results confirm the lack of androgen receptor expression in benign trichoblastic neoplasms and indicate that finding of androgen receptor expression points to basal cell carcinoma as the most likely diagnosis.
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DOI: 10.1111/j.0303-6987.2005.320dd.x
Affiliations:
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Izikson</name><affiliation></affiliation><affiliation><wicri:noCountry code="no comma">and Immunopathology Unit and</wicri:noCountry></affiliation></author><author><name sortKey="Bhan, A" sort="Bhan, A" uniqKey="Bhan A" first="A." last="Bhan">A. Bhan</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts General Hospital and Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Zembowicz, A" sort="Zembowicz, A" uniqKey="Zembowicz A" first="A." last="Zembowicz">A. Zembowicz</name><affiliation><wicri:noCountry code="no comma">and Immunopathology Unit and</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Cutaneous Pathology</title><title level="j" type="alt">JOURNAL OF CUTANEOUS PATHOLOGY</title><idno type="ISSN">0303-6987</idno><idno type="eISSN">1600-0560</idno><imprint><biblScope unit="vol">32</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="95">95</biblScope><biblScope unit="page" to="95">95</biblScope><biblScope unit="page-count">1</biblScope><publisher>Blackwell Publishing Ltd/Inc.</publisher><pubPlace>Oxford, UK; Malden, USA</pubPlace><date type="published" when="2005-01">2005-01</date></imprint><idno type="ISSN">0303-6987</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0303-6987</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Histological differentiation between basal cell carcinoma and benign trichoblastic neoplasms such as trichoepithelioma and trichoblastoma can be difficult on small biopsies. Therefore, several attempts have been made to identify immunohistochemical differences between these entities. Recent studies showed androgen receptor expression in a number of mature epithelial structures in the skin and in epithelial neoplasms including basal cell carcinoma. In contrast, androgen receptor expression was absent in mature hair follicles or the few trichogenic neoplasms studied to date. These findings suggested that androgen receptor expression might be a useful adjunct in the histological differential diagnosis between basal cell carcinoma and benign trichoblastic neoplasms. Therefore, we performed immunohistochemical analysis of androgen receptor expression in 32 basal cell carcinomas and 10 benign trichoblastic tumors (6 trichoepitheliomas and 4 trichoblastomas). In our study, expression of androgen receptor was detected in 78% of basal cell carcinomas. None of the trichoblastic tumors showed any androgen receptor immunoreactivity. These results confirm the lack of androgen receptor expression in benign trichoblastic neoplasms and indicate that finding of androgen receptor expression points to basal cell carcinoma as the most likely diagnosis.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><noCountry><name sortKey="Izikson, L" sort="Izikson, L" uniqKey="Izikson L" first="L." last="Izikson">L. Izikson</name><name sortKey="Zembowicz, A" sort="Zembowicz, A" uniqKey="Zembowicz A" first="A." last="Zembowicz">A. Zembowicz</name></noCountry><country name="États-Unis"><region name="Massachusetts"><name sortKey="Bhan, A" sort="Bhan, A" uniqKey="Bhan A" first="A." last="Bhan">A. Bhan</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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